Di-tert-butyl dicarbonate(CAS NO 24424-99-5)
Specification:
Item | Specification |
CAS NO | 24424-99-5 |
Molecular formular | C10H18O5 |
Molecular weight | 218.25 |
Linear formula | [(CH3)3COCO]2O |
EINECS NO | 246-240-1 |
State | White,low melting crystalline solid,high melting liquid |
Density（g/mL,25/4℃） | 0.95 g/mL at 25 °C(lit.) |
Melting Point（ºC） | 22-24 |
Boiling Point | 65-67 °C |
Refractive index | 1.4075-1.4095 |
Flash Point（ºC） | 37 |
Application:
In organic chemical reactions, di-tert-butyl dicarbonate is often used as a tert-butoxycarbonylation reagent for substrates such as amines, phenols, mercaptans, amides, lactams, and carbamates. The reaction rate is very fast and the yield is also Relatively high. Tert-butoxycarbonylation reaction (protection of functional groups); Due to the poor stability of acid halide reagents, di-tert-butyl dicarbonate is widely used as a protective group for amino groups, which is protected under acidic conditions (such as: Hydrochloric acid, trifluoroacetic acid, etc.) can be removed. Aliphatic amines, alicyclic amines, aromatic amines and heterocyclic amines can all react with di-tert-butyl dicarbonate.
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