Preparation of amino protective agent from 9-fluorene methanol
9-Fluorene methanol reacts with phosgene in a solvent to form Fmoc-CI. Due to the large-scale production of cheap and non-toxic solid triphosgene in recent years, replacing the highly toxic gas phosgene with it can not only make the reaction measurement accurate, the production process is safer and more reliable, but also greatly reduce equipment investment, thereby reducing reaction costs .
