Quinolinic acid (CAS NO 89-00-9)
Introduction:
Product name: Quinolinic acid
CAS NO: 89-00-9
Appearance: White crystal powder
Purity: ≥99%
Melting point: 188-190℃
Quinolinic acid (QUIN), a neuroactive metabolite of the kynurenine pathway, is normally presented in nanomolar concentrations in human brain and cerebrospinal fluid (CSF) and is often implicated in the pathogenesis of a variety of human neurological diseases. Quinolinic acid is an agonist of N-methyl-D-aspartate (NMDA) receptor, and it has a high in vivo potency as an excitotoxin. In fact, although Quinolinic acid has an uptake system, its neuronal degradation enzyme is rapidly saturated, and the rest of extracellular Quinolinic acid can continue stimulating the NMDA receptor. However, its toxicity cannot be fully explained by its activation of NMDA receptors it is likely that additional mechanisms may also be involved.
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