Di-tert-butyl dicarbonate（CAS NO 24424-99-5）
Specification:
Item | Specification |
CAS NO | 24424-99-5 |
Molecular formular | C10H18O5 |
Molecular weight | 218.25 |
Linear formula | [(CH3)3COCO]2O |
EINECS NO | 246-240-1 |
State | White,low melting crystalline solid,high melting liquid |
Density（g/mL,25/4℃） | 0.95 g/mL at 25 °C(lit.) |
Melting Point（ºC） | 22-24 |
Boiling Point | 65-67 °C |
Refractive index | 1.4075-1.4095 |
Flash Point（ºC） | 37 |
Advantage:
Di-tert-butyl dicarbonate is an amino acid protective agent with good performance. Compared with traditional amino acid protective agents such as benzyl chloroformate, chloroformic acid-P fluorenic acid, etc., it has the following advantages:
1. Di-tert-butyl dicarbonate is cheap
2. Di-tert-butyl dicarbonate has no strong irritating taste and is non-toxic to the human body. However, it can cause skin allergies when directly contacting the skin. It can be washed with water.
3. When using di-tert-butyl dicarbonate to synthesize peptides, the conditions for removing the protective gene are mild, and the separation and purification of the reaction product is easier than using other types of amino acid protective agents.
4. Di-tert-butyl dicarbonate is flammable, but not flammable or explosive
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