Tert-Butoxycarbonylation (protection of functional groups) Due to the poor stability of acyl halide reagents, di-tert-butyl dicarbonate is widely used as a protecting group for amino groups. The protective group can be removed under the action of trifluoroacetic acid. Aliphatic amines, alicyclic amines, aromatic amines and heterocyclic amines can all react with di-tert-butyl dicarbonate. Under appropriate conditions, multifunctional compounds such as diamines, amino alcohols, amino acids, etc. can also selectively react with di-tert-butyl dicarbonate.
