9-Fluorenylmethyl N-succinimidyl carbonate, an important compound, is widely used in organic synthesis, drug synthesis, pesticide synthesis and other fields. The following is the preparation method:
First, fluorenyl alcohol was added to tetrahydrofuran, then cuprous chloride was added, and the reaction chamber was stirred at constant temperature until the end of the reaction. Then, the tetrahydrofuran in the reaction solution is removed to obtain fluorene formyl compound. Then, fluorene formyl compound and succinate diester are added to sodium carbonate buffer, and heated to get fluorene formyl succinate diester. Finally, 9-Fluorenylmethyl N-succinimidyl carbonate was obtained by adding ammonia and fluorene formylsuccinate diester to ethanol and heating reaction.
The 9-Fluorenylmethyl N-succinimidyl carbonate prepared by this method is easy to operate, the reaction conditions are mild, the yield is high, and it is suitable for industrial large-scale production. 9-Fluorenylmethyl N-succinimidyl carbonate has a wide application prospect and plays an important role in promoting the development of organic synthesis, drug synthesis, pesticide synthesis and other fields.