What is di-tert-butyl dicarbonate? Chinese name: di-tert-butyl dicarbonate Chinese alias: di-tert-butyl dicarbonate, di-tert-butyl pyrocarbonate Common name: BOC English name: Di-tert-butyl dicarbonate Properties, function and synthesis method of di-tert-butyl dicarbonate
Properties and functions of di-tert-butyl dicarbonate
A new type of amino-protecting agent, used to introduce tert-butoxycarbonyl (BOC) protecting agent in organic synthesis, especially suitable for amino-protection of amino acids. Widely used in the synthesis of various products such as medicine, protein and peptide synthesis, biochemistry, food, cosmetics, etc. The finished product is a colorless crystal or colorless liquid, with a melting point of 22~23 °C, a boiling point of 56~57 °C/66 Pa, a refractive index (ND20) of 1.409, and a relative density (d4) of 0.950. Soluble in organic solvents such as tetrahydrofuran, n-hexane, benzene and chloroform, slightly soluble in water.
The synthetic method of di-tert-butyl dicarbonate
Potassium tert-butoxide is dissolved in anhydrous tetrahydrofuran, and dry carbon dioxide is introduced at -5 to -20°C to form a slurry, and the temperature is kept low, and phosgene and benzene solution are added dropwise to obtain di-tert-butyl tricarbonate. Dissolve it in carbon tetrachloride, add an appropriate amount of 1,4-diazabicyclo[2,2,2]octane, stir at 25°C to release carbon dioxide completely, and convert it into di-tert-butyl dicarbonate. font-size:10.5pt; font-family:Source Han Sans CN;mso-bidi-font-family:Source Han Sans CN;color:black;background:white;mso-ansi-language:EN-US;mso-fareast -language:ZH-CN;mso-bidi-language:AR-SA'>, sodium methoxide can also be used to replace the sodium hydroxide in the above method.