The chemical structure of indole
Indole is an aromatic heterocyclic organic compound which has a bicyclic structure on a chemical structure and contains a six-membered benzene ring and a five-membered nitrogen-containing pyrrole ring, so it is also called benzopyrrole. Because the lone pair of electrons of nitrogen participate in the formation of an aromatic ring, it is not a base, and its nature is different from that of a simple amine, which is an imine, which has a weak basicity; the double bond of a heterocyclic ring generally does not undergo an addition reaction; Under the action of strong acid, dimerization and tripolymerization can occur; under special conditions, aromatic electrophilic substitution reaction can be carried out, and hydrogen at the 3-position is preferentially substituted. For example, by reaction with sulfonyl chloride, 3-chloroindole can be obtained. . A variety of reactions can also occur at the 3-position, such as the formation of Grignard reagents, condensation with aldehydes, and Mannich reactions.