Isoquinoline (CAS NO 119-65-3)
Production:
Isoquinoline was first isolated from coal tar in 1885 by Hoogewerf and van Dorp.They isolated it by fractional crystallization of the acid sulfate. Weissgerber developed a more rapid route in 1914 by selective extraction of coal tar, exploiting the fact that isoquinoline is more basic than quinoline. Isoquinoline can then be isolated from the mixture by fractional crystallization of the acid sulfate.
Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. The Pomeranz–Fritsch reaction provides an efficient method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline. Alternatively, benzylamine and a glyoxal acetal can be used, to produce the same result using the Schlittler-Müller modification.
Application:
(1) Used as a stationary liquid and analytical reagent for gas chromatography, also used in the pharmaceutical industry.
(2) Production of drugs for the prevention and treatment of schistosomiasis (praziquantel), anti-malaria; rubber vulcanization accelerators, chemical reagents, etc.
About us
Xiaoyi Jinjing Chemical Co., Ltd., located in West of Xi Xie Bao Village, Xiabao Town, Xiaoyi City, Shanxi Province, covers an area of 20,000 square meters, is approved by Luliang City Economic and Trade Commission, established in 2006, legal representative Tian Xiaogang.
Over the years, the company adhere to the coal chemical industry chain extension for the development direction, has carried out a series of coal Chemical new materials research and development work, has made good progress.
In 2012 successfully developed a continuous deep processing of washing oil technology, to achieve the deep processing of coal tar three. In 2015 the company pioneered the development of industrial fluorene deep processing technology, in the end of 2016 successfully developed 9-fluorenone, 9-fluoren methanol, bisphenol fluorene fluorene series of polymer intermediates products, to fill the coal chemical fluorene products blank.
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